Long Survival Following Lung Transplantation: What Matters?
| Autor: | Zhao, Jane Y., Gouchoe, Doug A., Schwartzman, William E., Rosenheck, Justin P., Heh, Victor, Henn, Matthew C., Mokadam, Nahush A., Nunley, David R., Whitson, Bryan A., Ganapathi, Asvin M. |
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| Předmět: |
KRUSKAL-Wallis Test
HOMOGRAFTS CONFIDENCE intervals LUNG diseases LUNG transplantation MULTIVARIATE analysis AGE distribution MULTIPLE regression analysis PATIENTS GRAFT survival RETROSPECTIVE studies ACQUISITION of data FISHER exact test COMPARATIVE studies SEX distribution PSYCHOSOCIAL factors MEDICAL records DESCRIPTIVE statistics CHI-squared test RESEARCH funding DATA analysis software ODDS ratio TRANSPLANTATION of organs tissues etc. ORGAN donors ORGAN donation |
| Zdroj: | Transplantology; Dec2023, Vol. 4 Issue 4, p197-208, 12p |
| Abstrakt: | A retrospective review of the UNOS/OPTN Database was performed from 1 October 1987–31 December 2019. Recipients were classified as LSu (15+ years survival without GF/ReTx), normal survival (3–15 years) and short survival (<3 years). In total, 22,646 patients were identified. Groups were assessed with comparative statistics in addition to a multivariate analysis which included recipient, donor, transplant characteristics and select post-transplant complications. LSu recipients were younger, more commonly female, healthier and more commonly had cystic fibrosis, pulmonary vascular disease or bilateral lung transplantation. LSu donors were younger, healthier and lacked clinical infection. Recipients with restrictive lung disease, single lung transplant and dialysis postoperatively were less likely to be LSu. Several recipient, donor and transplant characteristics are associated with long lung transplantation survival. While some factors cannot be altered, others related to donor selection and posttransplant management can potentially be influenced. Understanding these characteristics and employing discretion in donor selection, in appropriate recipients, may optimize the longevity of transplanted lungs. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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