Dicarbonyl-Modified Low-Density Lipoproteins Are Key Inducers of LOX-1 and NOX1 Gene Expression in the Cultured Human Umbilical Vein Endotheliocytes.

Autor:	Lankin, Vadim Z., Sharapov, Mars G., Tikhaze, Alla K., Goncharov, Ruslan G., Antonova, Olga A., Konovalova, Galina G., Novoselov, Vladimir I.
Předmět:	LOW density lipoproteins UMBILICAL veins GENE expression ENDOTHELIAL cells ENDOTHELIUM diseases
Zdroj:	Biochemistry (00062979); Dec2023, Vol. 88 Issue 12/13, p2125-2136, 12p
Abstrakt:	Expression of LOX-1 and NOX1 genes in the human umbilical vein endotheliocytes (HUVECs) cultured in the presence of low-density lipoproteins (LDL) modified with various natural dicarbonyls was investigated for the first time. It was found that among the investigated dicarbonyl-modified LDLs (malondialdehyde (MDA)-modified LDLs, glyoxal-modified LDLs, and methylglyoxal-modified LDLs), the MDA-modified LDLs caused the greatest induction of the LOX-1 and NOX1 genes, as well as of the genes of antioxidant enzymes and genes of proapoptotic factors in HUVECs. Key role of the dicarbonyl-modified LDLs in the molecular mechanisms of vascular wall damage and endothelial dysfunction is discussed. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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