| Autor: |
TOK, Fatih, CİHANGİR, Hümeyra, ŞAN, Kader, ÇAKIR, Cansel, TUNA, Kübra, SICAK, Yusuf, ÖZTÜRK, Mehmet, KOÇYİĞİT-KAYMAKÇIOĞLU, Bedia |
| Předmět: |
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| Zdroj: |
Journal of Research in Pharmacy; 2023, Vol. 27 Issue 6, p2416-2424, 9p |
| Abstrakt: |
In this study, some new sulfonylurea derivatives based on the sulfanilamide compound were synthesized. IR, 1H-NMR, 13C-NMR spectroscopic methods and elemental analysis data were used to confirm the structures of the synthesized compounds. ABTS, DPPH, Cuprac and β-Carotene/linoleic acid assays were performed to evaluate the antioxidant activities of sulphonylurea derivatives. The activities of these compounds against some enzymes (acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase and α-glucosidase) were also investigated. Compounds S7, S8, S13 and S14 showed inhibitory activity against α-amylase enzyme with IC50 values of 227.84±1.48- 298.27±8.61 µM. In addition, the drug-likeness properties and solubility of the compounds were determined by computational programs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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