The Effect of Serum Laminin Level on Obstetric Outcomes in Pregnants with Preeclampsia.

Autor: Özer, Hale, Çaltek, Neçirvan Çağdaş, Özalp, Miraç, Çingillioğlu, Başak, Genç, Simten, Mihmanlı, Veli
Předmět:
Zdroj: European Archives of Medical Research; Dec2023, Vol. 39 Issue 4, p235-239, 5p
Abstrakt: Objective: To evaluate maternal serum laminin level in cases with preeclampsia, and to investigate the relationship of laminin with clinical parameters and perinatal outcomes in this case group. Methods: In this prospective observational study, 62 pregnant women with preeclampsia and 76 healthy normotensive pregnant women, matched for maternal age and body mass index, were evaluated. Maternal serum laminin levels were measured by ELISA and compared between groups. Results: Maternal serum laminin levels were significantly higher in the preeclampsia group (p=0.001). Laminin was significantly positively correlated with mean arterial pressure and amount of proteinuria (p=0.005, p=0.000; respectively), while significantly negatively correlated with umbilical cord pH and week of delivery (p=0.000, p=0.001; respectively). ROC curve analysis and Youden's index showed that the optimal threshold for laminin was 53.95 ng/mL when it comes to distinguishing pregnancies with preeclampsia from controls, with 65% sensitivity and 59% specificity. Conclusion: In conclusion, this study showed that serum laminin levels in pregnant women with preeclampsia were significantly higher than in the healthy normotensive control group. It was also reported that laminin levels were positively correlated with mean arterial pressure and proteinuria. We think that these findings point to the role of laminin in the pathogenesis of preeclampsia. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index