| Abstrakt: |
Objective: Neural activity in food reward‐ and appetite‐related regions was examined in response to high‐calorie (HC), low‐calorie, and non‐food pictures after exposure to written weight stigma (WS) content. Relationships with eating behavior (by Three‐Factor Eating Questionnaire [TFEQ]), blood glucose, and subjective appetite were also explored. Methods: Adults with overweight and obesity were randomized to read either a WS (n = 20) or control (n = 20) article and subsequently underwent brain scans while they rated pleasantness of food pictures. Fasting glucose, TFEQ, stigma experiences, and appetite were measured before reading the article, appetite after reading, and glucose and appetite again after the scan. Results: A priori region of interest analyses revealed significant group differences in activation to HC > low‐calorie food cues in the caudate and thalamus whereas exploratory whole‐brain analyses suggested significant differences in regions including left insula, left thalamus, left inferior temporal gyrus, right lingual gyrus, and bilateral middle occipital gyrus and superior parietal lobule (p < 0.005 uncorrected, k ≥ 200 m3). No significant relationships were observed between the pattern of activation and TFEQ, glucose, or subjective appetite in the WS group. Conclusions: Exposure to WS was associated with increased responsiveness to HC food content in the dorsal striatum and thalamus in individuals with overweight and obesity. [ABSTRACT FROM AUTHOR] |
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