| Autor: |
Wang, Yiqiao, Ding, Guanghong, Yao, Wei |
| Předmět: |
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| Zdroj: |
AppliedMath; Dec2023, Vol. 3 Issue 4, p758-770, 13p |
| Abstrakt: |
Based on the Hodgkin–Huxley theory, this paper establishes several nonlinear system models, analyzes the models' stability, and studies the conditions for repetitive discharge of neuronal membrane potential. Our dynamic analysis showed that the main channel currents (the fast transient sodium current, the potassium delayed rectifier current, and the fixed leak current) of a neuron determine its dynamic properties and that the GHK formula will greatly widen the stimulation current range of the repetitive discharge condition compared with the Nernst equation. The model including the change in ion concentration will lead to spreading depression (SD)-like depolarization, and the inclusion of a Na-K pump will weaken the current stimulation effect by decreasing the extracellular K accumulation. The results indicate that the Hodgkin–Huxley model is suitable for describing the response to initial stimuli, but due to changes in ion concentration, it is not suitable for describing the response to long-term stimuli. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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