| Autor: |
Jun Zhao, Yupeng Cao, Wentao Liu, Dong Han |
| Předmět: |
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| Zdroj: |
Magnetic Resonance Letter; Nov2023, Vol. 3 Issue 4, p286-297, 12p |
| Abstrakt: |
Interstitial fluid plays a vital role in drug delivery and tumour treatment. However, few non-invasive measurement methods are available for measuring low-velocity biological fluid flow. Therefore, this study aimed to develop a novel technology called interstitial flow velocity-MRI. The interstitial flow velocity-MRI sequence consists of a dual inversion recovery preparation and an improved stimulated echo sequence (ISTE) combined with phase-contrast MRI. A homemade flow phantom was used to assess the feasibility and sensitivity of interstitial flow velocity-MRI. In addition, xenografts of female BALB/c mouse models of 4T1 breast cancer administered losartan (40 mg/kg) or saline (n = 6) were subjected to imaging on a 7.0 T scanner to assess the in vivo interstitial fluid flow velocity. The results showed a significant correlation (P < 0.001) between the theoretical velocities and velocities measured using the flow phantom. Interstitial flow velocity-MRI could detect a velocity as low as 10.21 ± 2.65 μm/s with a spatial resolution of 0.313 mm. The losartan group had a lower mean interstitial fluid velocity than the control group (85 ± 16 vs 113 ± 24 μm/s). In addition, compared to the saline treatment, losartan treatment reduced the proportion of collagen fibres by 10% and 12% in the Masson and Sirius red staining groups, respectively. Interstitial flow velocity-MRI has the potential to determine interstitial fluid flow velocity non-invasively and exhibits an intuitive velocity map. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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