Retrospective Study of Treatment Patterns and Natural History of Patients with T1a/b N0 Triple-Negative Breast Cancers: A Single-Institution Experience.
| Autor: | Liu, Langfeier, Lewis, Nicholas, Sun, Weihong, Whiting, Junmin, Hoover, Susan, Costa, Ricardo L.B. |
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| Předmět: |
BREAST tumor treatment
KRUSKAL-Wallis Test CONFIDENCE intervals LOG-rank test IMMUNOHISTOCHEMISTRY RETROSPECTIVE studies FISHER exact test TUMOR classification RESEARCH funding CHI-squared test KAPLAN-Meier estimator GENE expression profiling ODDS ratio CANCER patient medical care BREAST tumors LONGITUDINAL method PROPORTIONAL hazards models |
| Zdroj: | Oncology; 2023, Vol. 101 Issue 12, p765-772, 8p |
| Abstrakt: | Introduction: T1a/b, node-negative (node−), triple-negative breast cancers (TNBCs) are underrepresented in randomized drug-approving clinical trials. Given their low incidence, the clinicopathological features, natural history, and treatment patterns of these tumors remain insufficiently understood. Methods: We conducted a single-institution retrospective cohort study of patients with T1a/b, N0, M0 TNBCs. Deidentified patient- and tumor-related data were collected and summarized. Kruskal-Wallis, χ2, or Fisher exact tests were used to evaluate associations of interest. Kaplan-Meier methods, log-rank tests, and Cox's proportional hazards models were applied for survival analyses. Results: Of 108 cases of node– TNBCs measuring ≤2 cm, 34 node– T1a/b tumors were included in our analysis. All cases had an intermediate to high histological grade, and most had a Ki-67 score of ≥20%. All patients received adjuvant chemotherapy, and many underwent mastectomy (47%). Docetaxel combined with cyclophosphamide was the most common adjuvant chemotherapy regimen (75%). We did not observe significant associations between improved outcomes and treatment with anthracycline-containing regimens. Among patients with node– pT1a/b tumors, the estimated 3-year recurrence-free survival (RFS) and distant RFS rates were both 96.3% (95% CI: 76.5–99.5), and the overall survival rate was estimated to be 100% (95% CI: 100–100). There were no cases of local recurrences observed. Conclusions: In our cohort, all patients with T1a/b node– TNBCs were treated with adjuvant chemotherapy and had favorable outcomes even when treated with anthracycline-sparing regimens. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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