| Abstrakt: |
A recent study conducted by researchers at China Medical University in Taichung, Taiwan, has found that hepatic events can occur after discontinuing antiviral therapy for hepatitis. The study compared hepatitis flares and hepatic decompensation in non-cirrhotic hepatitis B e antigen-negative patients who had discontinued either tenofovir disoproxil fumarate (TDF) or entecavir (ETV). The results showed that the cumulative rates of hepatitis flare at 6 months after discontinuing ETV and TDF were 2% and 19%, respectively, while the rates of hepatic decompensation were 0% and 7%. Factors such as higher alanine aminotransferase levels, rapid rebound of HBV DNA, and discontinuation of TDF were found to be independently associated with hepatitis flares. Older age and off-therapy dynamic change in HBV DNA were independently associated with hepatic decompensation. This study provides valuable insights into the factors associated with hepatic events after discontinuing antiviral therapy in non-cirrhotic hepatitis B e antigen-negative patients. [Extracted from the article] |
