| Autor: |
Khanna, Omaditya, Barsouk, Adam, Momin, Arbaz A., Mahtabfar, Aria, Andrews, Carrie E., Hafazalla, Karim, Lan, Matthews, Patel, Pious D., Baldassari, Michael P., Andrews, David W., Evans, James J., Farrell, Christopher J., Judy, Kevin D. |
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| Zdroj: |
Acta Neurochirurgica; Dec2023, Vol. 165 Issue 12, p4175-4182, 8p |
| Abstrakt: |
Purpose: Owing to their vicinity near the superior sagittal sinus, parasagittal and parafalcine meningiomas are challenging tumors to surgically resect. In this study, we investigate key factors that portend increased risk of recurrence after surgery. Methods: This is a retrospective study of patients who underwent resection of parasagittal and parafalcine meningiomas at our institution between 2012 and 2018. Relevant clinical, radiographic, and histopathological variables were selected for analysis as predictors of tumor recurrence. Results: A total of 110 consecutive subjects (mean age: 59.4 ± 15.2 years, 67.3% female) with 74 parasagittal and 36 parafalcine meningiomas (92 WHO grade 1, 18 WHO grade 2/3), are included in the study. A total of 37 patients (33.6%) exhibited recurrence with median follow-up of 42 months (IQR: 10–71). In the overall cohort, parasagittal meningiomas exhibited shorter progression-free survival compared to parafalcine meningiomas (Kaplan–Meier log-rank p = 0.045). On univariate analysis, predictors of recurrence include WHO grade 2/3 vs. grade 1 tumors (p < 0.001), higher Ki-67 indices (p < 0.001), partial (p = 0.04) or complete sinus invasion (p < 0.001), and subtotal resection (p < 0.001). Multivariable Cox regression analysis revealed high-grade meningiomas (HR: 3.62, 95% CI: 1.60–8.22; p = 0.002), complete sinus invasion (HR: 3.00, 95% CI: 1.16–7.79; p = 0.024), and subtotal resection (HR: 3.10, 95% CI: 1.38–6.96; p = 0.006) as independent factors that portend shorter time to recurrence. Conclusion: This study identifies several pertinent factors that confer increased risk of recurrence after resection of parasagittal and parafalcine meningiomas, which can be used to devise appropriate surgical strategy to achieve improved patient outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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