| Autor: |
Needleman, Sarah H., Kim, Mina, McClelland, Jamie R., Naish, Josephine H., Tibiletti, Marta, O'Connor, James P. B., Parker, Geoff J. M. |
| Předmět: |
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| Zdroj: |
Magnetic Resonance in Medicine; Mar2024, Vol. 91 Issue 3, p955-971, 17p |
| Abstrakt: |
Purpose: Dynamic lung oxygen‐enhanced MRI (OE‐MRI) is challenging due to the presence of confounding signals and poor signal‐to‐noise ratio, particularly at 3 T. We have created a robust pipeline utilizing independent component analysis (ICA) to automatically extract the oxygen‐induced signal change from confounding factors to improve the accuracy and sensitivity of lung OE‐MRI. Methods: Dynamic OE‐MRI was performed on healthy participants using a dual‐echo multi‐slice spoiled gradient echo sequence at 3 T and cyclical gas delivery. ICA was applied to each echo within a thoracic mask. The ICA component relating to the oxygen‐enhancement signal was automatically identified using correlation analysis. The oxygen‐enhancement component was reconstructed, and the percentage signal enhancement (PSE) was calculated. The lung PSE of current smokers was compared with nonsmokers; scan–rescan repeatability, ICA pipeline repeatability, and reproducibility between two vendors were assessed. Results: ICA successfully extracted a consistent oxygen‐enhancement component for all participants. Lung tissue and oxygenated blood displayed the opposite oxygen‐induced signal enhancements. A significant difference in PSE was observed between the lungs of current smokers and nonsmokers. The scan–rescan repeatability and the ICA pipeline repeatability were good. Conclusion: The developed pipeline demonstrated sensitivity to the signal enhancements of the lung tissue and oxygenated blood at 3 T. The difference in lung PSE between current smokers and nonsmokers indicates a likely sensitivity to lung function alterations that may be seen in mild pathology, supporting future use of our methods in patient studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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