Prediction of preterm delivery among low-risk indian pregnant women: Discriminatory power of cervical length, serum ferritin, and serum alpha-fetoprotein.

Autor: Jyothi, Lakavath, Datta, Mousumi, Mitra, Divyangana, Biswas, Jhuma, Maitra, Arghya, Kar, Kaushik
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Zdroj: International Journal of Applied & Basic Medical Research; Oct-Dec2023, Vol. 13 Issue 4, p198-203, 6p
Abstrakt: Background: Around 80% of preterm births (PTBs) occur spontaneously. Various biomarkers are being evaluated to assess the possible role of chorioamniotic inflammation in PTBs. Aim: The aim of this study was to establish the accuracy of serum bio-markers(cut off values of ferritin and alpha-fetoprotein [AFP] at midtrimester) along with cervical length [CL] assessment to predict preterm delivery among low-risk women. Methods: Three hundred low-risk pregnant women attending the antenatal clinic of a tertiary health care facility were included and underwent CL measurement during mid-trimester by transvaginal ultrasonography and their serum levels of ferritin and AFP were recorded. All were followed up till delivery. Results: Receptor-operated characteristic curves for ferritin, AFP, and CL were constructed. Area under curves and Youden Index calculated for each marker were very low (<0.5) which is statistically considered very poor for a screening test. Conclusion: Serum ferritin and AFP together with CL measurement in the second trimester of pregnancy had poor discriminatory value in predicting preterm delivery among low-risk asymptomatic pregnant women. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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