| Autor: |
Tabakam, Gaétan Tchangou, Kodama, Takeshi, Tchuenmogne, Marthe Aimée Tchuente, Hoang, Nhat Nam, Nomin-Erdene, Battsengel, Ngouela, Silvère Augustin, Tene, Mathieu, Morita, Hiroyuki, Awouafack, Maurice Ducret |
| Předmět: |
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| Zdroj: |
Natural Product Research; 2024, Vol. 38 Issue 2, p186-197, 12p |
| Abstrakt: |
In the search of cytotoxic dihydrochalcones, this investigation led to the isolation of seven compounds (1-7) from Eriosema glomeratum and the preparation of eight derivatives (8-15). The cytotoxicity of samples was evaluated against lung (A549), breast (MCF-7), and cervical (HeLa) human cancer cells. The CH2Cl2/MeOH extract of the aerial part had strong cytotoxicity against all cells [IC50 11.2 (MCF-7), 8.4 (HeLa) and 13.1 (A549) μg/mL]. A strong activity was also displayed by the n-hexane fraction on MCF-7 (IC50 11.2 μg/mL). The precursor 3 and the derivative 8 were specifically found as strong cytotoxic agents toward MCF-7 (7.6 μM) and HeLa (3.1 μM), respectively and were more effective than the positive control. Derivatives 8 (3.1 μM) and 9 (21.3 μM) against HeLa were most potent than their precursor 3 (23.7 μM). This is the first preparation of 8-14 as well as the cytotoxicity of 3, 4, 8-15, fractions, and extract. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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