Characterization of the novel temperate Escherichia coli phage phiStx2k.

Autor: Yang, Xi, Sui, Xinxia, Liu, Qian, Wang, Hua, Sun, Hui, Bai, Xiangning, Xiong, Yanwen
Zdroj: Archives of Virology; Jan2024, Vol. 169 Issue 1, p1-6, 6p
Abstrakt: A novel temperate phage, phiStx2k, was induced from a clinical Escherichia coli isolate producing Shiga toxin (Stx) 2k. The phage particles have an icosahedral head (50 nm in diameter) and a long non-contractile tail (149 nm long). The phage genome consists of 46,647 bp of double-stranded DNA with an average G + C content of 51%. Genome sequence comparisons suggested that phiStx2k represents a new genus in the class Caudoviricetes. phiStx2k was capable of converting non-Stx-producing E. coli strains to Stx producers. These results expand our knowledge on the characteristics of Stx phages and highlight the potential risks of the emergence of Stx-producing strains or novel pathogens via horizontal gene transfer. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index