Latent transforming growth factor beta binding protein 4: A regulator of mitochondrial function in acute kidney injury.

Autor:	Neikirk, Kit, Ume, Adaku C., Prasad, Praveena, Marshall, Andrea G., Rockwood, Jananie, Wenegieme, Tara‐Yesomi, McMichael, Kelia E., McReynolds, Melanie R., Williams, Clintoria R., Hinton, Antentor
Předmět:	TRANSFORMING growth factors-beta ACUTE kidney failure CARRIER proteins TRANSFORMING growth factors MITOCHONDRIA RENAL fibrosis
Zdroj:	Aging Cell; Dec2023, Vol. 22 Issue 12, p1-6, 6p
Abstrakt:	Recently, latent transforming growth factor beta binding protein 4 (LTBP4) was implicated in the pathogenesis of renal damage through its modulation of mitochondrial dynamics. The seminal article written by Su et al. entitled "LTBP4 (Latent Transforming Growth Factor Beta Binding Protein 4) Protects Against Renal Fibrosis via Mitochondrial and Vascular Impacts" uncovers LTBP4's renoprotective role against acute kidney injury via modulating mitochondrial dynamics. Recently, LTBP4 has emerged as a driver in the mitochondrial‐dependent modulation of age‐related organ pathologies. This article aims to expand our understanding of LTBP4's diverse roles in these diseases in the context of these recent findings. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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