| Autor: |
Kellaway, C. H., Trethewie, E. R. |
| Zdroj: |
Australian Journal of Experimental Biology & Medical Science; Jun1941, Vol. 19 Issue 2, p77-87, 11p, 9 Graphs |
| Abstrakt: |
The toxins of Cl. welchii Types B and C injected intravenously have similar effects on the circulation of cats, both causing a rise in pressure in the pulmonary artery and a terminal steep fall in systemic pressure often accompanied by heart block and invariably by a sharp rise of venous pressure. The first effect with smaller doses of 1 type C toxin is a prolonged rise of systemic blood pressure. The toxin of Cl. welchii type B causes the liberation of histamine from the perfused lung of the cat, but fails to do so from the perfused lung of the guinea-pig. The toxin of Cl. welchii type C causes the liberation of a slow reacting muscle stimulant substance from both preparations. Both toxins cause the liberation from the perfused liver of the rabbit of pigment, of adenyl compounds and of a heat labile agent which inactivates these latter compounds. Both toxins cause contraction of the isolated jejunum of the guinea-pig and of the uteri of the virgin guinea-pig and rat. These responses were shown to be specific except that of the isolated uterus of the guinea-pig to type B toxin--in which a histamine-like impurity was present. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text