Epigenetic signatures of cfDNA enable a topological assignment of tissue damage.

Autor: Gerhards, Catharina, Evliyaoglu, Osman, Ast, Volker, Neumaier, Michael
Předmět:
Zdroj: Clinical Chemistry & Laboratory Medicine; Jan2024, Vol. 62 Issue 2, pe37-e39, 3p
Abstrakt: This article discusses the potential use of epigenetic signatures of cell-free DNA (cfDNA) as biomarkers for identifying tissue damage. The authors analyzed the epigenetic signatures of cfDNA in COVID-19 patients and found that varying proportions of releasing cells and involvement of other organ systems could differentiate between severe and milder cases of the disease. They also presented a case study of a patient with a significantly elevated prostate signal in their cfDNA, which could potentially aid in diagnosing prostate cancer. The authors suggest that analyzing epigenetic patterns of cfDNA could be a cost-effective and minimally invasive method for screening and identifying cell damage. [Extracted from the article]
Databáze: Complementary Index