| Abstrakt: |
New research from McMaster University in Canada has identified pyrimidine biosynthesis as a potential target for treating brain metastasis, the spread of cancer cells to the brain. The researchers found that inhibiting the enzyme dihydroorotate dehydrogenase (DHODH), which is involved in pyrimidine biosynthesis, decreased the viability and growth of metastatic brain tumor cells in vitro and in vivo. This study suggests that DHODH inhibitors could be promising therapeutic agents for brain metastasis. The research was presented at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics. [Extracted from the article] |
