Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico Researcher Updates Current Study Findings on Chronic Myeloid Leukemia (Efficacy of Frontline Treatment with Initial Low-Dose Tyrosine-Kinase Inhibitors in Elderly Patients with Chronic...).

Předmět:	CHRONIC myeloid leukemia OLDER patients PROTEIN-tyrosine kinase inhibitors RESEARCH personnel FRAIL elderly
Zdroj:	Drug Week; 12/22/2023, p893-893, 1p
Abstrakt:	A recent study conducted by researchers at the Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico in Italy examined the efficacy of frontline treatment with low-dose tyrosine-kinase inhibitors (TKIs) in elderly patients with chronic myeloid leukemia (CML). The study analyzed data from 747 CML patients aged over 65 years who were treated with reduced-dose TKIs. The researchers found that reduced-dose TKIs were mainly used in frail elderly patients with comorbidities and concomitant therapies. While there were no differences in the rate of major molecular response (MMR), the rate of deep molecular response (DMR) achievement was lower in patients treated with reduced-dose TKIs. However, longer follow-up is needed to confirm these results. [Extracted from the article]
Databáze:	Complementary Index
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