| Abstrakt: |
Researchers from NITTE Deemed University in Karnataka, India have formulated and evaluated chitosan-coated PLGA nanoparticles of ashwagandha extract. The nanoparticles were designed to address issues such as intestinal absorption, burst release of the drug, and bioavailability. The optimized formulation showed smooth, spherical, and uniform particles with good entrapment efficiency. In vitro studies demonstrated sustained drug release, enhanced antioxidant activity, and better efficacy in cancer cells. This research provides insights into the potential of mucoadhesive chitosan-coated PLGA nanoparticles for colon-targeted drug delivery. [Extracted from the article] |
