Findings in HIV/AIDS Reported from Centers for Disease Control and Prevention (Prolonged mpox disease in people with advanced HIV: characterization of mpox skin lesions).

Předmět:	MONKEYPOX AIDS HIV SEXUALLY transmitted diseases DENDRITIC cells IMMUNE reconstitution inflammatory syndrome
Zdroj:	AIDS Weekly; 12/18/2023, p43-43, 1p
Abstrakt:	A recent report from the Centers for Disease Control and Prevention (CDC) discusses three cases of prolonged mpox disease in individuals with advanced HIV who were not receiving antiretroviral therapy (ART) at the time of diagnosis. The researchers used various medical countermeasures, including prolonged tecovirimat treatment and immune optimization with ART initiation. Skin biopsies showed a dense immune response and abundant replication of monkeypox virus (MPXV) in epithelial cells and dendritic cells. These findings suggest that ongoing MPXV replication may contribute to prolonged mpox in individuals with advanced HIV, highlighting the need for aggressive medical interventions and immune optimization. [Extracted from the article]
Databáze:	Complementary Index
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