Recent Studies from Northwestern University Add New Data to Antineoplastic Monoclonal Antibodies (Addition of Trastuzumab Deruxtecan to Selpercatinib in a Patient With RET Fusion-Driven NSCLC and an Acquired HER2 Amplification: Case Report).

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Zdroj: Immunotherapy Weekly; 12/19/2023, p1868-1868, 1p
Abstrakt: A recent study conducted by researchers at Northwestern University highlights the need for comprehensive molecular testing in patients with uncommon driver mutations. The study focused on a patient with RET fusion-driven non-small cell lung cancer (NSCLC) who developed resistance to selective RET inhibitors. The patient was initially treated with chemotherapy and immune therapy, then switched to selpercatinib, and eventually had fam-trastuzumab deruxtecan added to their treatment. The case demonstrates the importance of identifying unexpected resistance mechanisms and underscores the need for thorough molecular testing at both diagnosis and progression. [Extracted from the article]
Databáze: Complementary Index