| Autor: |
Ramesh, Uma, Contrera, Kevin J., Shakibai, Nasim, Su, Shirley Y., Brahimaj, Bledi, Roberts, Dianna, Williams, Michelle D., Ferrarotto, Renata, Phan, Jack, Gunn, Gary Brandon, Raza, Shaan, DeMonte, Franco, Hanna, Ehab Y. |
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| Zdroj: |
Head & Neck; Jan2024, Vol. 46 Issue 1, p29-36, 8p |
| Abstrakt: |
Background: Sinonasal NUT carcinoma is an extremely rare, lethal malignancy with limited literature. Methods: A case series was conduction of all patients with sinonasal NUT carcinoma at a single institution between 2010 and 2022. Survival and associated were evaluated. A systematic review of the literature was performed. Results: In 12 patients, followed for a median of 1.5 years, the median overall survival (OS) and disease‐specific survival (DSS) were both 14.6 months. Patients with maxillary sinus tumors were 91% more likely to survive (hazard ratio [HR]: 0.094, 95% confidence interval [CI]: 0.011–0.78, p = 0.011). Patients with higher‐stage disease stage had worse OS (stage IVb‐c vs. III‐IVa, p = 0.05). All three patients who were alive with no evidence of disease received induction chemotherapy. Conclusion: For patients with sinonasal NUT carcinoma, the median survival was 15 months but better with lower‐stage and maxillary tumors. Induction chemotherapy may be beneficial. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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