In HIV-Infected Immunological Non-Responders, Hepatitis C Virus Eradication Contributes to Incomplete Normalization of Systemic Inflammation Indexes, but Does Not Lead to Rapid CD4+ T-Cell Count Recovery.

Autor:	Saidakova, E. V., Korolevskaya, L. B., Shmagel, N. G., Vlasova, V. V., Shardina, K. Yu., Chereshnev, V. A., Shmagel, K. V.
Předmět:	HEPATITIS C virus T cells CD4 antigen HEPATITIS C ANTIVIRAL agents HIGHLY active antiretroviral therapy
Zdroj:	Doklady Biochemistry & Biophysics; Oct2023, Vol. 512 Issue 1, p274-278, 5p
Abstrakt:	In HIV-positive individuals taking antiretroviral therapy, coinfection with hepatitis C virus (HCV) increases systemic inflammation, which interferes with the CD4+ T-cells regeneration. This study evaluated the effect of HCV eradication on systemic inflammation and CD4+ T-cell regeneration in patients who gave poor response to antiretroviral therapy, the so-called "immunological non-responders" (INRs). HIV-infected patients who received a course of direct-acting antivirals for treating hepatitis C were examined. The control groups included HIV/HCV-coinfected INRs and relatively healthy volunteers. It was established for the first time that HCV eradication is not accompanied by a complete suppression of systemic inflammation, but improves the T-cell pool composition: in INRs, the blood CD4+/CD8+ T-lymphocyte ratio increases and approaches those of healthy individuals. Apparently, in INRs treated for hepatitis C, the immune system recovery takes time and may be incomplete. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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