| Autor: |
Grewal, Nimrat, Dolmaci, Onur, Klautz, Arthur, Legue, Juno, Driessen, Antoine, Klautz, Robert, Poelmann, Robert |
| Zdroj: |
Indian Journal of Thoracic & Cardiovascular Surgery; 2023 Suppl2, Vol. 39, p270-279, 10p |
| Abstrakt: |
A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is associated with an increased risk to develop a thoracic aortic aneurysm and/or an aortic dissection as compared to persons with a tricuspid aortic valve. Due to the high prevalence of a BAV in the general population and the associated life-long increased risk for adverse vascular events, BAV disease places a considerable burden on the public health. The aim of the present review is to discuss the role of transforming growth factor beta (TGF-β) signaling in the development of the vascular wall and on how this complex signaling pathway may be involved in thoracic aortic aneurysm formation in tricuspid and BAV patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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