Galectin-3 and its correlation with carotid ultrasound in rheumatoid arthritis patients.
| Autor: | Amer, Arwa S., Soliman, Amal Fathy, |
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| Předmět: |
PROTEINS
BIOMARKERS CARDIOVASCULAR diseases risk factors RESEARCH CASE-control method RISK assessment SEVERITY of illness index CAROTID artery ultrasonography RHEUMATOID arthritis DISEASE duration DESCRIPTIVE statistics ENZYME-linked immunosorbent assay STATISTICAL correlation RECEIVER operating characteristic curves SENSITIVITY & specificity (Statistics) COMORBIDITY |
| Zdroj: | Egyptian Rheumatology & Rehabilitation; 12/11/2023, Vol. 50 Issue 1, p1-9, 9p |
| Abstrakt: | Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease resulting in disability as well as joint damage. Early diagnosis and treatment are crucial for improving outcomes. RA patients have a twofold elevated risk of cardiovascular disease (CVD) development compared to the general population. Carotid ultrasound is a noninvasive imaging modality that can detect early signs of atherosclerosis and plaque buildup in the carotid arteries, which are strongly associated with CVD risk. Galectin-3 (Gal-3), a protein involved in inflammation and fibrosis, is suggested as one of the potential RA markers. Despite the growing interest in galectin-3 as a biomarker for CVD, few studies have investigated its role in RA patients. To our knowledge, only two studies have examined the correlation between galectin-3 and CVD in RA patients, and they have yielded conflicting results. This study aimed to determine the serum level of Gal-3 as well as its correlation with carotid ultrasound assessment for cardiovascular involvement in RA patients. Results: RA cases demonstrated substantially elevated Gal-3 levels than controls (P < 0.001), and a 3.38 pg/mL cut-off value was proven to be an excellent predictor of RA diagnosis (AUC, 0.98). Gal-3 levels were proven to be positively associated with DAS-28, Larsen score, and carotid intima-media thickness (CIMT) (P-value 0.006, 0.026, < 0.001, respectively). A positive association was also detected between right (RT) and left (LT) CIMT and disease duration (P-values of 0.040 and 0.042, respectively). Conclusions: Gal-3 is a biomarker for RA that is not only associated with activity and severity of the disease but it is also related to the chronicity of the disease and is a predictor of cardiovascular comorbidity. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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