| Autor: |
S. O., Onoja, A. C., Ezeigbo, N. E., Udeh, G., Daniel-Igwe, I. C., Unamba-Oparah, U., Akpabio, P. I., Otuh, K. G., Madubuike, A., Onyeabor, E., Ejiofor, M. E., Ohanwe, Obasi-Uwalaka, N. I., E. O., Ekundayo, V. O., Anosa |
| Předmět: |
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| Zdroj: |
Journal of Sustainable Veterinary & Allied Sciences; Sep2023, Vol. 5 Issue 1, p16-25, 10p |
| Abstrakt: |
This study investigated the phytochemical composition, antioxidant and acaricidal properties of methanol and chloroform extracts of Cymbopogon citratus leaf. A known quantity of the pulverized plant material was first exhaustively extracted with chloroform and thereafter, with methanol using a Soxhlet apparatus set at 40 °C. The extracts were concentrated in a hot air oven at 40 °C. Gas chromatography-mass spectroscopy was used to determine the phytochemical composition, while 1,1 diphenyl-2-picrylhydraxyl (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) assay were used to evaluate the antioxidant profile of the extracts at concentrations of 25 - 400 µg/mL. Contact method was used to investigate the acaricidal property and molecular docking analysis of selected identified compounds were performed against acetylcholinesterase to check their drug like potentials. Fifty-seven and sixty-four compounds were identified in the methanol and chloroform extracts, respectively. The methanol extract produced higher antioxidant and acaricidal properties (P < 0.05) relative to the chloroform extract. The compounds formed hydrogen bonds with amino acid residues. In conclusion; the methanol extract demonstrated better antioxidant and acaricidal properties than the chloroform extract, which could be linked to the higher concentration of essential oil (Carvomenthol, (-)-carvone, and eucalyptol) in the methanol extract. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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