| Abstrakt: |
Researchers from Zhejiang University of Technology in Hangzhou, China, have conducted a study on potential treatments for Alzheimer's disease. They designed and synthesized a series of chromone-hydroxypyridinone hybrids as potential anti-AD ligands. One compound, 17d, showed promising iron-chelating potential and selective monoamine oxidase B (MAO-B) inhibitory activity. It was also found to cross the blood-brain barrier and improve cognitive impairment in AD mice. Although further investigation is needed, compound 17d shows potential as a multifaceted agent for the treatment of Alzheimer's disease. [Extracted from the article] |
