Researchers from Cold Spring Harbor Laboratory Report Recent Findings in Liver Cancer (Crispr-induced Exon Skipping of B-catenin Reveals Tumorigenic Mutants Driving Distinct Subtypes of Liver Cancer).

Předmět:	LIVER cancer SPRING RESEARCH personnel GAIN-of-function mutations HEPATOCELLULAR carcinoma
Zdroj:	Cancer Weekly; 12/12/2023, p1033-1033, 1p
Abstrakt:	Researchers from Cold Spring Harbor Laboratory have made new findings in liver cancer, specifically in relation to CRISPR/Cas9 technology. The researchers discovered that using CRISPR/Cas9 to target a specific gene called Ctnnb1 resulted in exon skipping and the generation of gain-of-function isoforms in vivo. This led to the formation of liver tumors in mice. The researchers also identified similar exon-skipping events in patients with hepatocellular carcinoma. These findings contribute to our understanding of beta-catenin-related tumorigenesis and demonstrate the potential of CRISPR/Cas9 for studying gain-of-function mutations in cancer. [Extracted from the article]
Databáze:	Complementary Index
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