| Abstrakt: |
A recent study conducted by researchers at the University of Southern Denmark investigated the effects of a fatty acid amide hydrolase (FAAH) inhibitor in the laterodorsal tegmental nucleus (LDT) using a new ex vivo mouse preparation. The LDT is a crucial part of the brainstem reticular activating system, involved in regulating sleep, arousal, and addiction. The study aimed to characterize the lipids and neuronal activity in the LDT by exposing mouse brain slices to the FAAH inhibitor. Metabolomics and proteomic analyses were conducted, revealing differences in the LDT with and without the inhibitor. The researchers concluded that this ex vivo preparation could be useful for screening different FAAH inhibitors and further characterizing omics profiles within the LDT. [Extracted from the article] |
