| Abstrakt: |
A recent report from Pune, India discusses the development of a new protocol for the synthesis of 3,3'-bis(indolyl)methanes (BIMs) using prolinium hydrogen sulfate (ProHSO4) as a catalyst. The method allows for the production of BIMs in high yields at room temperature without the need for solvents or support materials. In silico studies were conducted on the synthesized BIMs, revealing their potential as protein targets for anticancer activity. Several derivatives were identified as potential inhibitors of Eg5 kinesin, Human p38 a MAP Kinase, and Human 3 alpha HSD type 3, warranting further evaluation in biological experimental systems. [Extracted from the article] |
