Study Findings on Melanoma Are Outlined in Reports from Rega Institute for Medical Research (Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma).

Předmět:	ENDOTHELIAL cells MEDICAL research RESEARCH institutes AUTOPHAGY RESEARCH personnel MELANOMA
Zdroj:	Immunotherapy Weekly; 12/14/2023, p2958-2958, 1p
Abstrakt:	A recent study conducted by the Rega Institute for Medical Research has found that tumor endothelial cells (TECs) play a crucial role in suppressing immune responses and maintaining an immune-excluded tumor phenotype in melanoma. The researchers discovered that inhibiting autophagy in TECs enhances antitumor immunity by promoting the infiltration and function of T-cells, thereby restricting melanoma growth. The study also revealed that patients who responded well to immunotherapy exhibited an enriched inflammatory TEC phenotype. These findings highlight the importance of autophagy as a key mechanism in tumor vascular anti-inflammatory processes in melanoma. [Extracted from the article]
Databáze:	Complementary Index
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