OBSERVATIONS ON INITIAL EXTRACTION OF POSTERIOR LOBE PITUITARY POWDERS RELEVANT TO THE ONE-MULTIPLE THEORIES OF PITUITARY HORMONE PRODUCTION.

Autor: Waring, H., Landgrebe, F. W.
Zdroj: Australian Journal of Experimental Biology & Medical Science; Aug1956, Vol. 34 Issue 4, p263-268, 5p, 3 Charts
Abstrakt: Extracts of both Int. St. P and commercial powder were made under different conditions of pH. These extracts were subjected to activated charcoal adsorption and the residual pressor and oxytocic activities were assayed at intervals during adsorption. Extracts of Int. St. P. made at pH 3-3 did not show differential adsorption of the activities; extracts of commercial powder made at pH 3.3 showed slower and reduced differential adsorption as compared with extracts made at higher pH. The conclusion is drawn that the differing adsorption properties of pressor and oxytocic activities in pituitary powder extracts are due to the degree of hydrolysis permitted by the extraction procedure. This tends to support the view that these activities are part of a single 'parent' molecule in the pituitary gland. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index