| Autor: |
Diningrat, Diky S., Marwani, Erly, Kusdianti |
| Předmět: |
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| Zdroj: |
Tropical Journal of Natural Product Research; Nov2023, Vol. 7 Issue 11, p5195-5202, 8p |
| Abstrakt: |
Acne is generally associated with Propionibacterium acnes, which is treated by administering anti-acne medication. The anti-acne drugs currently available are synthetic ingredients that cause side effects. The side effects of this synthetic anti-acne drug can be eliminated by chemicals derived from natural plants, such as those found in teak flower (Tectona grandis) essential oil. Therefore, this study aims to determine bioactive compounds' content and test teak essential oil's anti-acne activity. The steps taken in this research: The extraction of teak flower essential oil is made by steam distillation. The teak flower essential oil was then analyzed using a Gas Chromatography Mass Spectrophotometer (GC-MS). The results were evaluated using the MASLAB program and then analyzed using the PubChem NCBI database and PASS Online. The results of the GC-MS analysis showed that there were 47 bioactive compounds. The PubChem analysis results showed that 13 compounds had antibacterial activity. The antibacterial activity as an anti-acne agent of teak flower essential oil was assessed using the disc diffusion method according to the Bauer method. The results of the PASS Online analysis showed that the antibacterial mechanism, Protein synthesis inhibitor, membrane permeability inhibitor and cell wall synthesis inhibitor, with the highest Pa value of 0.804 in the compound Benzyl benzoate Benzoic acid, phenylmethyl ester (CAS) and the lowest Pa value was 1H-Benzimidazole, 2-(methylthio)-(CAS) 2-thiomethylbenzimidazole. Based on the results of the antibacterial activity test, it has strong activity against Propionibacterium acnes with an inhibition zone value of 23.1; 15; 15.4; 11.3 which has the potential as an anti-acne. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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