| Autor: |
Tsai, Chih-Ming, Caldera, Jr, Hajam, Irshad A., Liu, George Y. |
| Předmět: |
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| Zdroj: |
Expert Review of Vaccines; 2023, Vol. 22 Issue 1, p207-209, 3p |
| Abstrakt: |
This article discusses the challenges in developing an effective vaccine for Staphylococcus aureus (S. aureus), a leading cause of infection and antibiotic resistance. Despite numerous vaccine trials, there has not been a successful S. aureus vaccine. The article focuses on a study that suggests immune imprinting, caused by prior exposure to S. aureus, may be the reason for vaccine failures. The study found that antibodies generated in mice previously infected with S. aureus were non-protective and interfered with the efficacy of the vaccine. The article suggests further investigation into the effect of immune imprinting on vaccine outcomes and the development of vaccines targeting different antigens. It also discusses potential strategies to overcome immune imprinting, such as targeting subdominant epitopes and modulating Fc glycosylation. The article concludes by highlighting the need to rethink traditional vaccine development strategies for pathogens like S. aureus. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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