Exercise Improves Physical Capacity, Cognition, Quality of Life and Promotes Neurotrophic Factors in Patients with Multiple Sclerosis.

Autor:	AÇIK, Mehmet, ŞENIŞIK, Seçkin, TAŞKIRAN, Dilek, AKŞİT, Tolga, AYDINOĞLU, Ramazan, YÜCEYAR, Ayşe Nur
Předmět:	AEROBIC capacity NERVE growth factor MULTIPLE sclerosis COGNITION disorders SEDENTARY lifestyles GRIP strength KRUSKAL-Wallis Test STATISTICS ANALYSIS of variance POSTURAL balance OXYGEN consumption CARDIOPULMONARY fitness FUNCTIONAL status COGNITION EXERCISE physiology OXYGEN saturation CYCLING PEARSON correlation (Statistics) RANDOMIZED controlled trials MUSCLE strength QUALITY of life BODY movement HEART beat ENZYME-linked immunosorbent assay CHI-squared test RESEARCH funding FATIGUE (Physiology) DATA analysis software DATA analysis SYMPTOMS
Zdroj:	Archives of Neuropsychiatry / Nöropsikiyatri Arşivi; Dec2023, Vol. 60 Issue 4, p335-343, 9p
Abstrakt:	Introduction: We aimed to determine the effect of regular exercise on aerobic capacity, strength values, and plasma levels of Nerve Growth Factor (NGF) and Neurotrophin-3 (NT-3) in patients with multiple sclerosis (MS) and investigate its effects on MS symptoms including cognitive impairment, fatigue, balance disorders, and quality of life (QOL). Methods: Forty-three relapsing-remitting MS patients with an Expanded Disability Status Scale (EDSS) score of 4 or less participated in the study. Participants were divided into three groups: aerobic group, strength group, and control group. The patients in the exercise groups had exercise programs three days a week for three months. Aerobic capacity (maximum VO2 value), strength measurements, and balance tests were done, and NGF and NT-3 plasma levels were analyzed in all participants at the beginning and end of the study. Multiple Sclerosis Quality of Life- 54 (MSQoL-54), fatigue impact scale, Pittsburgh Sleep Quality Index (PSQI) and, to evaluate cognitive functions, BICAMS scale were applied. Results: Aerobic exercise and strength exercise groups had significant increases in VO2 max, back and leg strength values, and NGF and NT-3 plasma levels (p<0.01). Cognitive functions, fatigue, sleep quality, and QOL significantly improved in the exercise groups (p<0.01). The balance values were also significantly improved in the aerobic group (p<0.01), and although improvement although improvement was observed in the strength group, it was not statistically significant (p>0.05). Conclusions: Our study provides evidence that regular exercise improves quality of life, cognitive functions, fatigue, and sleep quality in MS patients. The levels of NGF and NT-3, which are important factors in neural regeneration and remyelination, were increased post exercise. It can be suggested that exercise may have a potential effect on MS and slow down the disease process with these results. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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