Leveraging cascade alkynyl Prins cyclization towards the stereoselective synthesis of spiro-furan quinazolinone scaffolds.

Autor: Biswas, Subhamoy, Shit, Sudip, Behera, Bipin Kumar, Sahu, Archana Kumari, Saikia, Anil K.
Předmět:
Zdroj: Chemical Communications; 12/14/2023, Vol. 59 Issue 96, p14301-14304, 4p
Abstrakt: A TfOH-promoted, metal-free protocol has been unveiled for the synthesis of spiro-furan quinazolinones employing alkynol urea derivatives utilizing alkynyl Prins cyclization reaction. This methodology produces highly functionalized spiro-heterocycles in excellent yields with exclusive E-selectivity under ambient conditions. Furthermore, late-stage modifications incorporate bromide and acetyl functionalities into the synthesized spiro-heterocycles. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index