Structures and biological activity of three 2‐(pyridin‐2‐yl)‐1H‐benzimidazole derivatives.

Autor:	Sukiennik, Jarosław, Olczak, Andrzej, Gobis, Katarzyna, Korona-Głowniak, Izabela, Suśniak, Katarzyna, Fruziński, Andrzej, Szczesio, Małgorzata
Předmět:	MORPHOLOGY NUCLEAR magnetic resonance spectroscopy CRYSTAL structure GRAM-positive bacteria ANTI-infective agents
Zdroj:	Acta Crystallographica Section C: Structural Chemistry; Dec2023, Vol. 79 Issue 12, p504-512, 9p
Abstrakt:	Two new 2‐(pyridin‐2‐yl)‐1H‐benzimidazole derivatives, namely, 2‐(4‐phenoxypyridin‐2‐yl)‐1H‐benzimidazole, C18H13N3O, and 2‐[4‐(4‐fluorophenoxy)pyridin‐2‐yl]‐1H‐benzimidazole, C18H12FN3O, were synthesized and characterized by NMR spectroscopy. Crystal structure, biological activity and ADME analyses were performed for these two new compounds and a third compound, namely, 5,6‐dimethyl‐2‐[4‐(4‐phenylpiperazin‐1‐yl)pyridin‐2‐yl]‐1H‐benzimidazole methanol monosolvate, C24H25N5·CH3OH, the synthesis of which had been described previously. All three compounds have a similar chain hydrogen‐bonding pattern. One of them (the fluorophenoxy derivative) showed good antimicrobial activity against Gram‐positive bacteria. The ADME analysis indicates that the compounds could be good drug candidates. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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