Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-disubstituted alkenes enabling the modular synthesis of 1,1,2,2-tetraarylethanes.

Autor: Zhang, Chengxi, Xi, Yang, Qu, Jingping, Chen, Yifeng
Zdroj: SCIENCE CHINA Chemistry; Dec2023, Vol. 66 Issue 12, p3539-3545, 7p
Abstrakt: The highly diastereoselective dicarbofunctionalization of substituted olefins still remains a daunting challenge in synthetic chemistry. Herein, we report a Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-diarylethylene with chelation group free to enable the modular synthesis of smart material candidates, 1,1,2,2-tetraarylethanes (TAEs), which represent the first protocol by assembling four different aryl groups into ethane motif. Preliminary mechanistic experiments suggest that the crucial Pd-H species generated in situ do not disengage from the alkene intermediate during the reaction. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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