COVID-19 infection, admission and death and the impact of corticosteroids among people with rare autoimmune rheumatic disease during the second wave of COVID-19 in England: results from the RECORDER Project.

Autor:	Rutter, Megan, Lanyon, Peter C, Grainge, Matthew J, Hubbard, Richard, Bythell, Mary, Stilwell, Peter, Aston, Jeanette, McPhail, Sean, Stevens, Sarah, Pearce, Fiona A
Předmět:	DRUG therapy for rheumatism ADRENOCORTICAL hormones NATIONAL health services PATIENTS RESEARCH funding HOSPITAL admission & discharge TREATMENT effectiveness DESCRIPTIVE statistics AUTOIMMUNE diseases CONFIDENCE intervals COMPARATIVE studies COVID-19 COVID-19 pandemic RHEUMATISM EVALUATION
Zdroj:	Rheumatology; Dec2023, Vol. 62 Issue 12, p3828-3837, 10p
Abstrakt:	Objectives To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the second wave of the COVID-19 pandemic in England, and describe the impact of corticosteroids on outcomes. Methods Hospital Episode Statistics data were used to identify people alive on 1 August 2020 with ICD-10 codes for RAIRD from the whole population of England. Linked national health records were used to calculate rates and rate ratios of COVID-19 infection and death up to 30 April 2021. Primary definition of COVID-19-related death was mention of COVID-19 on the death certificate. NHS Digital and Office for National Statistics general population data were used for comparison. The association between 30-day corticosteroid usage and COVID-19-related death, COVID-19-related hospital admissions and all-cause deaths was also described. Results Of 168 330 people with RAIRD, 9961 (5.92%) had a positive COVID-19 PCR test. The age-standardized infection rate ratio between RAIRD and the general population was 0.99 (95% CI: 0.97, 1.00). 1342 (0.80%) people with RAIRD died with COVID-19 on their death certificate and the age–sex-standardized mortality rate for COVID-19-related death was 2.76 (95% CI: 2.63, 2.89) times higher than in the general population. There was a dose-dependent relationship between 30-day corticosteroid usage and COVID-19-related death. There was no increase in deaths due to other causes. Conclusions During the second wave of COVID-19 in England, people with RAIRD had the same risk of COVID-19 infection but a 2.76-fold increased risk of COVID-19-related death compared with the general population, with corticosteroids associated with increased risk. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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