Recombinant Clostridium perfringens alpha-N-Acetylgalactosaminidase Blood Group A 2 Degrading Activity.

Autor:	Hsin-Yeh, Hsieh, Chapman, Linda F., Calcutt, Michael J., Mitra, Moonmoon, Smith, Daniel S.
Předmět:	ABO blood group system BLOOD group antigens ERYTHROCYTES MEMBRANE proteins MEMBRANE lipids GLYCOPROTEINS IMMUNE response
Zdroj:	Artificial Cells, Blood Substitutes & Biotechnology; May2005, Vol. 33 Issue 2, p187-199, 13p
Abstrakt:	This article reports that the ABO blood group antigens (A, B, and H antigens) are composed of complex oligosaccharides linked to membrane proteins and lipids and abundant on red blood cell membranes. Exoglycosidases are enzymes that modify carbohydrate epitopes on glycoproteins and glycolipids by cleaving specific monosaccharide units from the non-reducing ends, thereby modulating the immune response. Some exoglycosidases modify the A, B and H antigens by hydrolysis of the terminal immunodominant residue.
Databáze:	Complementary Index
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