| Autor: |
Yanagisawa, Akira, Hinata, Yuki, Midorikawa, Koji, Watanabe, Takamichi |
| Předmět: |
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| Zdroj: |
Synlett; Dec2023, Vol. 34 Issue 20, p2515-2519, 5p |
| Abstrakt: |
This article explores the use of chiral tin catalysts in the asymmetric α-cyanation of β-keto esters. The researchers found that the reaction proceeded with significant asymmetric induction, and they optimized the solvent, determining that THF was the most effective. The presence of certain groups on the ester and the steric hindrance of the alkyl substituent were found to be important factors in achieving asymmetric induction. The authors successfully synthesized nonracemic α-cyano-β-keto esters with high optical purities and demonstrated the scalability of the reaction. Future studies will focus on expanding the range of substrates used in the reaction. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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