TCR-α/β and CD19 depleted stem cell grafts from haploidentical donors for allogeneic transplantation in patients with relapsed lymphoma: a single-center experience.

Autor:	Kenkre, Vaishalee P., Bradley, Kristin, Milton, Arissa, Burkholder, Joseph K., Grindle, Kreg, McMannes, Jan, Kim, KyungMann, Callander, Natalie, Juckett, Mark, Longo, Walter, Hematti, Peiman
Předmět:	STEM cell transplantation STEM cells CD19 antigen BLOOD diseases NEPHROTOXICOLOGY CARDIOTOXICITY
Zdroj:	Leukemia & Lymphoma; Nov2023, Vol. 64 Issue 11, p1875-1879, 5p
Abstrakt:	This document provides a summary of a study conducted on adult patients with relapsed lymphoma who underwent a haploidentical stem cell transplant. The study aimed to evaluate the feasibility and outcomes of depleting TCR α/β + and CD19+ cells from the graft. The study included 11 patients who successfully engrafted and had low rates of acute and chronic graft-versus-host disease (GVHD). However, the study was closed prematurely due to a high rate of cardiac and renal toxicity. The authors suggest that future studies should consider alternative conditioning regimens and focus on patients with hematologic diseases. [Extracted from the article]
Databáze:	Complementary Index
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