Predictive value of combined serum IL-6 with UREA on severity of neonatal pneumonia: an observational study.
| Autor: | Li, Ci, Xu, Zhe, Sun, Hongqi, Yang, Liu, Nie, Manjie, Gong, Weihua, Yang, Junmei, Li, Tiewei |
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| Předmět: |
PNEUMONIA diagnosis
INTERLEUKINS GLOMERULAR filtration rate STATISTICS PREDICTIVE tests UREA SCIENTIFIC observation CONFIDENCE intervals ANALYSIS of variance NEONATAL diseases CROSS-sectional method MULTIPLE regression analysis MULTIVARIATE analysis MANN Whitney U Test COMPARATIVE studies PEARSON correlation (Statistics) T-test (Statistics) CHI-squared test DESCRIPTIVE statistics RESEARCH funding RECEIVER operating characteristic curves ODDS ratio DATA analysis software DATA analysis SENSITIVITY & specificity (Statistics) CHILDREN |
| Zdroj: | Journal of Laboratory Medicine; Dec2023, Vol. 47 Issue 6, p251-256, 6p |
| Abstrakt: | IL-6 is an inflammatory marker and urea nitrogen (UREA) is a common indicator of glomerular filtration function. Their combined detection has predictive value for the severity of neonatal pneumonia. We performed a cross-sectional analysis of the clinical and laboratory data, collected from 105 neonatal patients (including 76 mild to moderate pneumonia patients and 29 severe pneumonia patients). Mann–Whitney U-test showed serum IL-6 and UREA levels were significantly increased in severe pneumonia, compared with that in mild to moderate pneumonia (p<0.05). Correlation analysis showed the severity of neonatal pneumonia was positively correlated with serum IL-6 (r=0.284, p<0.05) and UREA (r=0.303, p<0.05) levels. Multivariate logistic regression analysis showed the increased levels of IL-6 (OR=1.002, 95 % CI 1.001–1.004) and UREA (OR=1.420, 95 % CI 1.046–1.926) were independent risk factors for the severity of neonatal pneumonia. ROC curve analysis showed that the predictive value of combined detection of serum IL-6 and UREA in the severity of neonatal pneumonia was better than that of either detection alone (area under curve [AUC] = 0.809, 95 % CI 0.711–0.894, p<0.001). Combined detection of IL-6 and UREA had a good predictive value for evaluating the severity of neonatal pneumonia. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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