Role of Coagulation Parameters and Inflammatory Biomarkers in Coronavirus Disease 2019 Patients: A Demystifying Endeavor.
| Autor: | Kumarguru, B. N., Sreegiri, Sindhu, Swathi, D., Ramaswamy, A. S., Arathi, C. A. |
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| Předmět: |
BIOMARKERS
PROTHROMBIN time PARTIAL thromboplastin time C-reactive protein COVID-19 SCIENTIFIC observation ANALYSIS of variance INFLAMMATION FERRITIN RETROSPECTIVE studies T-test (Statistics) PLATELET count LACTATE dehydrogenase DESCRIPTIVE statistics BLOOD coagulation factors INTERNATIONAL normalized ratio DATA analysis software FIBRIN fibrinogen degradation products SARS disease |
| Zdroj: | Journal of Applied Hematology; Jul-Sep2023, Vol. 14 Issue 3, p214-224, 11p |
| Abstrakt: | BACKGROUND: Coronavirus disease 2019 (COVID-19) globally known as COVID-19 is a heterogeneous disease caused by the severe acute respiratory syndrome coronavirus 2. COVID-19 patients having severe disease and are critically ill are more prone to have abnormal coagulation prolife. It may lead to thromboinflammation in severe conditions. AIM: The aim is to evaluate the utility of coagulation parameters and inflammatory biomarkers in COVID-19 patients in the study conducted for 6 months duration. MATERIALS AND METHODS: It was a retrospective observational study conducted from April 2021 to September 2021 in a rural tertiary care referral Institute. Available data of the baseline values of coagulation parameters (platelet count [PLC], prothrombin time [PT], international normalized ratio [INR], partial thromboplastin time [PTT] and D-dimer) and inflammatory markers (C-reactive protein [CRP], serum lactate dehydrogenase [LDH], and serum ferritin) were evaluated with respect to the clinical severity of the disease and also the survival status of COVID-19 patients. RESULTS: One hundred and fifty-five cases of COVID-19-positive patients were analyzed. PT, INR, PTT, D-dimer, CRP, LDH, and ferritin had higher mean in severe cases than the nonsevere cases. PLC had higher mean in the severe cases than the nonsevere cases. PT, INR, PTT, D-dimer, CRP, LDH and ferritin had higher mean in nonsurvivors than the survivors. PLC had lower mean in nonsurvivors than the survivors. CONCLUSION: Baseline values of PT, INR, PTT, D-dimer, LDH, and ferritin may be considered reliable indicators of severity of COVID-19 disease. Baseline values of D-dimer, LDH, and ferritin may be considered a reliable indicator of survival of patients suffering from COVID-19 infection. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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