| Autor: |
Sephton, Thomas, Charitou, Anastasios, Trujillo, Cristina, Large, Jonathan M., Butterworth, Sam, Greaney, Michael F. |
| Předmět: |
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| Zdroj: |
Angewandte Chemie International Edition; 12/4/2023, Vol. 62 Issue 49, p1-7, 7p |
| Abstrakt: |
Anilines are potentially high‐value arylating agents, but are limited by the low reactivity of the strong C−N bond. We show that the reactive intermediate benzyne can be used to both activate anilines, and set‐up an aryl transfer reaction in a single step. The reaction does not require any transition metal catalysts or stoichiometric organometallics, and establishes a metal‐free route to valuable biaryl products by functionalizing the aniline C−N bond. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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