| Autor: |
Garza, Raquel, Sharma, Yogita, Atacho, Diahann A.M., Thiruvalluvan, Arun, Abu Hamdeh, Sami, Jönsson, Marie E., Horvath, Vivien, Adami, Anita, Ingelsson, Martin, Jern, Patric, Hammell, Molly Gale, Englund, Elisabet, Kirkeby, Agnete, Jakobsson, Johan, Marklund, Niklas |
| Zdroj: |
Cell Reports; Nov2023, Vol. 42 Issue 11, pN.PAG-N.PAG, 1p |
| Abstrakt: |
Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a unique transcriptional response in oligodendrocyte precursors and mature oligodendrocytes, including the activation of a robust innate immune response, indicating an important role for oligodendroglia in the initiation of neuroinflammation. The activation of an innate immune response correlated with transcriptional upregulation of endogenous retroviruses in oligodendroglia. This observation was causally linked in vitro using human glial progenitors, implicating these ancient viral sequences in human neuroinflammation. In summary, this work provides insight into the initiating events of the neuroinflammatory response in TBI, which has therapeutic implications. [Display omitted] • Unique snRNA-seq analysis of human TBI tissue • Activation of an interferon response in oligodendroglia after TBI • Expression of endogenous retroviruses in TBI oligodendroglia From transcriptional profiling of human brain tissue after acute TBI, Garza et al. find an oligodendroglia-specific innate immune response, correlated with transcriptional activation of endogenous retroviruses in the same cell types. The results provide insight into the beginning of human neuroinflammation and implicate endogenous retroviruses in this process. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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