Stereoselective Synthesis of Highly Functionalized Aminobenzothiazole-Fused Spirooxindole Derivatives: in silico and in vitro Anti-Diabetic Studies.

Autor: Nivetha, Narayanasamy, Patil, Shashank M., Ramu, Ramith, Sreenivasa, Swamy, Velmathi, Sivan
Předmět:
Zdroj: Synthesis; Dec2023, Vol. 55 Issue 24, p4145-4162, 18p
Abstrakt: This document provides a detailed account of the synthesis and characterization of various compounds, specifically aminobenzothiazole-fused spirooxindole derivatives. The compounds were synthesized using a three-component 1,3-dipolar cycloaddition reaction and were found to have high yields and specificity. The document also includes information on the chemical properties of the compounds, as well as in vitro enzyme inhibition assays and molecular docking simulations. The findings suggest that these compounds have potential applications in the field of medicinal chemistry. [Extracted from the article]
Databáze: Complementary Index