Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma.

Autor:	Da Silva, Léa, Klopfenstein, Timothée, Gendrin, Vincent, Clouet, Julien, Toko, Lynda, Richier, Quentin, Leriche, Thomas, Nicolas, Raoul, Queijo, Alexis, Sreiri, Nour, Lacombe, Karine, Zayet, Souheil
Předmět:	CONVALESCENT plasma COVID-19 treatment SARS-CoV-2 TREATMENT effectiveness MONOCLONAL antibodies REVERSE transcriptase polymerase chain reaction
Zdroj:	Viruses (1999-4915); Nov2023, Vol. 15 Issue 11, p2220, 8p
Abstrakt:	We highlighted in this current paper similar prolonged respiratory presentation with COVID-19 pneumonia in four severely immunocompromised patients currently being treated with anti-CD20 monoclonal antibodies (mAbs), such as ocrelizumab and rituximab, for multiple sclerosis or rheumatoid polyarthritis. Real-time reverse transcription-polymerase chain reaction on a nasopharyngeal swab specimen was negative in all patients. SARS-CoV-2 infection was confirmed from bronchoalveolar lavage fluid. A high titer of post-vaccine COVID-19 convalescent plasma was administered with complete recovery in all patients. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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