| Autor: |
Correa-Gallegos, Donovan, Ye, Haifeng, Dasgupta, Bikram, Sardogan, Aydan, Kadri, Safwen, Kandi, Ravinder, Dai, Ruoxuan, Lin, Yue, Kopplin, Robert, Shenai, Disha Shantaram, Wannemacher, Juliane, Ichijo, Ryo, Jiang, Dongsheng, Strunz, Maximilian, Ansari, Meshal, Angelidis, Illias, Schiller, Herbert B., Voltz, Thomas, Machens, Hans-Günther, Rinkevich, Yuval |
| Zdroj: |
Nature; Nov2023, Vol. 623 Issue 7988, p792-802, 11p |
| Abstrakt: |
Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation1. Here we identify a multipotent fibroblast progenitor marked by CD201 expression in the fascia, the deepest connective tissue layer of the skin. Using skin injury models in mice, single-cell transcriptomics and genetic lineage tracing, ablation and gene deletion models, we demonstrate that CD201+ progenitors control the pace of wound healing by generating multiple specialized cell types, from proinflammatory fibroblasts to myofibroblasts, in a spatiotemporally tuned sequence. We identified retinoic acid and hypoxia signalling as the entry checkpoints into proinflammatory and myofibroblast states. Modulating CD201+ progenitor differentiation impaired the spatiotemporal appearances of fibroblasts and chronically delayed wound healing. The discovery of proinflammatory and myofibroblast progenitors and their differentiation pathways provide a new roadmap to understand and clinically treat impaired wound healing.Spatiotemporal regulation of wound healing in mice and humans occurs via retinoic acid and hypoxia signalling, which regulate the differentiation of CD201+ fibroblast progenitors into proinflammatory and myofibroblast states. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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Full text from SpringerLink